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Home / Primary Antibodies

STAT1 Antibody

SKU : BHA10557852

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA697883
Alternative Names	Signal transducer and activator of transcription 1; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.Schindler C., Proc. Natl. Acad. Sci. U.S.A. 89:7836-7839(1992).Hillier L.W., Nature 434:724-731(2005).Yan R., Nucleic Acids Res. 23:459-463(1995).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human STAT1.
Involvement In Disease	Immunodeficiency 31B (IMD31B); Immunodeficiency 31A (IMD31A); Immunodeficiency 31C (IMD31C)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Schindler C., Proc. Natl. Acad. Sci. U.S.A. 89:7836-7839(1992). Hillier L.W., Nature 434:724-731(2005). Yan R., Nucleic Acids Res. 23:459-463(1995).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total STAT1 protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P42224
Database Links	HGNC:11362 OMIM:600555 KEGG:hsa:6772 STRING:9606.ENSP00000354394 UniGene:Hs.642990
Function	Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus
Pathway	Chemokine signaling pathway Jak-STAT signaling pathway Nitric oxide signaling MAPK Erk pathway Necroptosis NOD-like receptor signaling pathway Osteoclast differentiation Th1 and Th2 cell differentiation Th17 cell differentiation Toll-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications
Protein Families	Transcription factor STAT family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557852	CSB-PA697883	100ul	$297		Add to Cart

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