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Home / Primary Antibodies

ST5 Antibody

SKU : BHA10557889

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA195797
Alternative Names	Suppression of tumorigenicity 5; HeLa tumor suppression 1; DENN domain-containing protein 2B; ST5; DENND2B
Categories	Primary Antibodies
Clonality	polyclonal
Description	Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.Lichy J.H., Nucleic Acids Res. 24:4700-4708(1996).Amid C., Cytogenet. Cell Genet. 93:284-290(2001).Lichy J.H., Cell Growth Differ. 3:541-548(1992).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human ST5.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth. Lichy J.H., Nucleic Acids Res. 24:4700-4708(1996). Amid C., Cytogenet. Cell Genet. 93:284-290(2001). Lichy J.H., Cell Growth Differ. 3:541-548(1992).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ST5 protein.

Uniprot	P78524
Database Links	HGNC:11350 OMIM:140750 KEGG:hsa:6764 STRING:9606.ENSP00000319678 UniGene:Hs.117715
Function	Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.
Tissue Specificity	Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557889	CSB-PA195797	100ul	$297		Add to Cart

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