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Home / Antibodies

SS18 Antibody

SKU : BHA10557636

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA173100
Alternative Names	SSXT; MGC116875;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.de Bruijn D.R., dos Santos N.R., Thijssen J., Balemans M., Debernardi S., Linder B., Young B.D., Geurts van Kessel A.Oncogene 20:3281-3289(2001)dIwasaki T., Koibuchi N., Chin W.W.Endocrinology 146:3892-3899(2005)
Host	Rabbit
Immunogen	Peptide sequence around aa.14~18(G-E-I-T-P) derived from Human SYT.
Involvement In Disease	A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. de Bruijn D.R., dos Santos N.R., Thijssen J., Balemans M., Debernardi S., Linder B., Young B.D., Geurts van Kessel A.Oncogene 20:3281-3289(2001) dIwasaki T., Koibuchi N., Chin W.W.Endocrinology 146:3892-3899(2005)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total SYT protein.
Subcellular Location	Nucleus

Uniprot	Q15532
Database Links	HGNC:11340 OMIM:600192 KEGG:hsa:6760 STRING:9606.ENSP00000414516 UniGene:Hs.129261
Function	Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.
Protein Families	SS18 family
Tissue Specificity	Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557636	CSB-PA173100	100ul	$297		Add to Cart

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