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Home / Antibodies

SRCIN1 Antibody

SKU : BHA10558835

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA574977
Alternative Names	p130Cas-associated protein; P140; p140Cap; SNAP-25-interacting protein;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.Oka M., Submitted (DEC-2003).Sugano S., Nat. Genet. 36:40-45(2004).Ohara O., DNA Res. 7:347-355(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human SNIP.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. Oka M., Submitted (DEC-2003). Sugano S., Nat. Genet. 36:40-45(2004). Ohara O., DNA Res. 7:347-355(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total SNIP protein.
Subcellular Location	Cytoplasm, Cytoplasm, cytoskeleton, Cell projection, axon, Cell projection, dendrite, Cell junction, synapse, Cell junction, synapse, postsynaptic cell membrane, postsynaptic density

Uniprot	Q9C0H9
Database Links	HGNC:29506 OMIM:610786 KEGG:hsa:80725 STRING:9606.ENSP00000264659 UniGene:Hs.448872
Function	Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
Protein Families	SRCIN1 family
Tissue Specificity	Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558835	CSB-PA574977	100ul	$297		Add to Cart

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