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Home / Primary Antibodies

SPIN1 Antibody

SKU : BHA10558070

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA548594
Alternative Names	OCR; Ovarian cancer-related protein; Spindlin-1;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.Zhang H.L., Chin. Sci. Bull. 45:909-914(2000). Gao Y., Biochem. Biophys. Res. Commun. 335:343-350(2005).Humphray S.J., Nature 429:369-374(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human SPIN1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. Zhang H.L., Chin. Sci. Bull. 45:909-914(2000). Gao Y., Biochem. Biophys. Res. Commun. 335:343-350(2005). Humphray S.J., Nature 429:369-374(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total SPIN1 protein.
Subcellular Location	Nucleus, Nucleus, nucleolus

Uniprot	Q9Y657
Database Links	HGNC:11243 OMIM:609936 KEGG:hsa:10927 STRING:9606.ENSP00000365019 UniGene:Hs.146804
Function	Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway
Protein Families	SPIN/STSY family
Tissue Specificity	Highly expressed in ovarian cancer tissues.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558070	CSB-PA548594	100ul	$297		Add to Cart

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