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SP100 Antibody

SKU : BHA10558549

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA102856
Alternative Names	DKFZp686E07254; FLJ00340; FLJ34579; Lysp100b; nuclear antigen Sp100
Categories	Primary Antibodies
Clonality	polyclonal
Description	Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to . Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to . Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.Dent A.L., Blood 88:1423-1426(1996).Seeler J.-S., Proc. Natl. Acad. Sci. U.S.A. 95:7316-7321(1998).Szostecki C., J. Immunol. 145:4338-4347(1990).
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human SP100.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to . Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to . Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. Dent A.L., Blood 88:1423-1426(1996). Seeler J.-S., Proc. Natl. Acad. Sci. U.S.A. 95:7316-7321(1998). Szostecki C., J. Immunol. 145:4338-4347(1990).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total SP100protein.
Subcellular Location	Nucleus, Nucleus, PML body, Cytoplasm, Note=Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon-dependent, Accumulates in the cytoplasm upon FAS activation, SUBCELLULAR LOCATION: Isoform Sp100-C: Nucleus

Uniprot	P23497
Gene Id	6672
Database Links	HGNC:11206 OMIM:604585 KEGG:hsa:6672 STRING:9606.ENSP00000343023 UniGene:Hs.369056
Function	Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed
Tissue Specificity	Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.
Weight	50,032 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558549	CSB-PA102856	100ul	$297		Add to Cart

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