Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency Yuan H, et al. Genes Dev. 1995 Nov 1;9(21):2635-45Muta M, et al. Genes Cells 2002 Aug;7(8):791-805 Tomioka M, et al. Nucleic Acids Res. 2002 Jul 15; 30(14): 3202-3213.
Host
Rabbit
Immunogen
Peptide sequence around aa.76~80 (G-A-E-W-K) derived from SOX2
Involvement In Disease
Microphthalmia, syndromic, 3 (MCOPS3)
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency
Yuan H, et al. Genes Dev. 1995 Nov 1;9(21):2635-45 Muta M, et al. Genes Cells 2002 Aug;7(8):791-805 Tomioka M, et al. Nucleic Acids Res. 2002 Jul 15; 30(14): 3202-3213.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of total SOX2 protein.
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Pathway
Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.