Mouse Anti-Human Sodium-Iodide Symporter Monoclonal IgG1

Mfr.No.	SMC-390, SMC-390D, SMC-390D-A390, SMC-390D-A488, SMC-390D-A594, SMC-390D-ALP, SMC-390D-APC, SMC-390D-BI, SMC-390D-FITC, SMC-390D-HRP, SMC-390D-PCP, SMC-390D-RPE, SMC-390S
Immunogen Species	Human
Alternative Names	NIS Antibody, SLC5A5 Antibody, solute carrier family 5 Antibody, Na (+)I(-) cotransporter Antibody
Categories	Antibodies
Cellular Localization	Membrane
Certificate Of Analysis	1 ug/ml of SMC-390 was sufficient for detection of hNIS in 20 ug of transfected COS-7 cell membrane lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Human Sodium-Iodide Symporter Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Mannose binding protein hNIS fusion (AA468-643), Homo Sapiens (Human)
Immunogen Region	Mannose binding protein hNIS fusion (AA468-643)
Isotype	IgG1
Launch Date	2011/05/01
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	Q92911
Accession Number	NP_000444.1
Gene Id	6528
Target	Sodium Iodide Symporter
Clone No	14F
Research Area	Pumps/Transporters, Cell Signaling, Cancer, Ion Pumps/Transporters, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), IHC (1:1000); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	The sodium iodide symporter (NIS) is an ion pump that actively transports iodide across the basolateral membrane into thyroid epithelial cells (1, 2). This is important step in the process of iodide organificaton and the formation of triiodothyronine and thyroxine (3).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~97kDa, non-glycosylated version at 68kDa. Other minor bands associated with hNIS at 160kDa, and degradation products at ~30 kDa, and ~15kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, IHC, WB
Description	WB ; IHC ; AM
Dilution	WB (1:1000), IHC (1:1000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Dai G., Levy O., Carrasco N. (1996) Nature. 379(6564): 458-460. 2. Snabik P.A., et al. (1997) Endocrin. 138(8): 3555-3558. 3. Dohan O., et al. (2007) Proc Natl Acad Sci USA. 104(51): 20250-20255.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11903317-1	SMC-390D	Unconjugated	100 ug	$330	Add to Cart
BHA11903317-2	SMC-390D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11903317-3	SMC-390D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11903317-4	SMC-390D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11903317-5	SMC-390D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11903317-6	SMC-390D-APC	APC	100 ug	$382	Add to Cart
BHA11903317-7	SMC-390D-BI	Biotin	100 ug	$378	Add to Cart
BHA11903317-8	SMC-390D-FITC	FITC	100 ug	$374	Add to Cart
BHA11903317-9	SMC-390D-HRP	HRP	100 ug	$370	Add to Cart
BHA11903317-10	SMC-390D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11903317-11	SMC-390D-RPE	RPE	100 ug	$380	Add to Cart
BHA11903317-12	SMC-390S	Unconjugated	12 ug	$44	Add to Cart

Sodium Iodide Symporter Antibody, Clone 14F - SMC-390