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Home / Primary Antibodies

SOCS3 Antibody (F53719)

SKU : BHA17119844

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NSJ Bioreagents

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Mfr.No.	F53719-0.1ML
Clonality	Monoclonal (mouse origin)
Description	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
Formulation	In ascites with 0.09% sodium azide
Host	Mouse
Immunogen Region	This SOCS3 antibody was produced from a mouse immunized with recombinant protein of human SOCS3.
Isotype	Mouse IgM
Species Reactivity	Human
Note	Titration of the SOCS3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Uniprot	O14543

Format	Ascites
Purity	Ascites
Storage	Aliquot the SOCS3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA
Description	Weste blot: 1:500-1:1600

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17119844	F53719-0.1ML	0.1 ml	$379		Add to Cart

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