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Home / Antibodies

SNCA (Ab-125) Antibody

SKU : BHA10557665

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA578342
Alternative Names	alpha-synuclein; NACP; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; SYN
Categories	Primary Antibodies
Clonality	polyclonal
Description	May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.Ueda K., Proc. Natl. Acad. Sci. U.S.A. 90:11282-11286(1993).Campion D., Genomics 26:254-257(1995).Ueda K., Biochem. Biophys. Res. Commun. 205:1366-1372(1994).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Synuclein-α around the phosphorylation site of tyrosine 125 (E-A-Y(p)-E-M)., Synthesized non-phosphopeptide derived from Human Synuclein-α around the phosphorylation site of tyrosine 125 (E-A-Y(p)-E-M).
Involvement In Disease	Parkinson disease 1, autosomal dominant (PARK1); Parkinson disease 4, autosomal dominant (PARK4); Dementia Lewy body (DLB)
Raised In	Rabbit, Rabbit
Reactivity	Human, Mouse, Mouse, Rat
Regulatory	RUO
Relevance	May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Ueda K., Proc. Natl. Acad. Sci. U.S.A. 90:11282-11286(1993). Campion D., Genomics 26:254-257(1995). Ueda K., Biochem. Biophys. Res. Commun. 205:1366-1372(1994).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Synuclein-α protein., The antibody detects endogenous levels of total Synuclein-α protein.
Subcellular Location	Cytoplasm, cytosol, Membrane, Nucleus, Cell junction, synapse, Secreted

Uniprot	P37840
Gene Id	6622, 6622
Database Links	HGNC:11138 OMIM:127750 KEGG:hsa:6622 STRING:9606.ENSP00000338345 UniGene:Hs.21374
Function	May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation., May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Protein Families	Synuclein family
Tissue Specificity	Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Weight	14460 MW, 14460 MW

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze., Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557665	CSB-PA578342	100ul	$297		Add to Cart

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