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Home / Antibodies

SNAI1 (Ab-246) Antibody

SKU : BHA10557661

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA041790
Alternative Names	SNAH; SNAI; Sna; Snail; zinc finger protein SNAI1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.Okubo T., Cancer Res. 61:1338-1346(2001).Twigg S.R., Hum. Genet. 105:320-326(1999).Paznekas W.A., Genomics 62:42-49(1999)
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human SNAI1 around the phosphorylation site of serine 246 (T-F-S(p)-R-M).
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. Okubo T., Cancer Res. 61:1338-1346(2001). Twigg S.R., Hum. Genet. 105:320-326(1999). Paznekas W.A., Genomics 62:42-49(1999)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total SNAI1 protein.
Subcellular Location	Nucleus, Cytoplasm

Uniprot	O95863
Database Links	HGNC:11128 OMIM:604238 KEGG:hsa:6615 STRING:9606.ENSP00000244050 UniGene:Hs.48029
Function	Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Pathway	Adherens junction
Protein Families	Snail C2H2-type zinc-finger protein family
Tissue Specificity	Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557661	CSB-PA041790	100ul	$297		Add to Cart

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