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Home / Antibodies

SMG7 Antibody

SKU : BHA10559348

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA226815
Alternative Names	C1orf16; EST1C; KIAA0250;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.Ohnishi T., Mol. Cell 12:1187-1200(2003).Nagase T., DNA Res. 3:321-329(1996).Nakajima D., DNA Res. 9:99-106(2002).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human SMG7.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Ohnishi T., Mol. Cell 12:1187-1200(2003). Nagase T., DNA Res. 3:321-329(1996). Nakajima D., DNA Res. 9:99-106(2002).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total SMG7 protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q92540
Database Links	HGNC:16792 OMIM:610964 KEGG:hsa:9887 UniGene:Hs.591463
Function	Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559348	CSB-PA226815	100ul	$297		Add to Cart

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