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Home / Primary Antibodies

SLCO1B1 Antibody

SKU : BHA10558701

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA081369
Alternative Names	Solute carrier family 21 member 6; Sodium-independent organic anion-transporting polypeptide 2; OATP 2; Liver-specific organic anion transporter 1; LST-1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Mediates the Na+-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.Kirchgessner T.G., J. Biol. Chem. 274:37161-37168(1999).Keppler D., J. Biol. Chem. 275:23161-23168(2000).Venter J.C., Submitted (JUL-2005).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human SLCO1B1.
Involvement In Disease	Hyperbilirubinemia, Rotor type (HBLRR)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Mediates the Na+-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. Kirchgessner T.G., J. Biol. Chem. 274:37161-37168(1999). Keppler D., J. Biol. Chem. 275:23161-23168(2000). Venter J.C., Submitted (JUL-2005).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total SLCO1B1 protein.
Subcellular Location	Basolateral cell membrane, Multi-pass membrane protein

Uniprot	Q9Y6L6
Database Links	HGNC:10959 OMIM:237450 KEGG:hsa:10599 STRING:9606.ENSP00000256958 UniGene:Hs.449738
Function	Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Protein Families	Organo anion transporter (TC 2.A.60) family
Tissue Specificity	Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558701	CSB-PA081369	100ul	$297		Add to Cart

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