Na(+)/H(+) exchanger 9; NHE-9; Solute carrier family 9 member 9;
Categories
Primary Antibodies
Clonality
polyclonal
Description
May act in electroneutral exchange of protons for Na+ across membranes. Involved in the effusion of Golgi luminal H+ in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.De Silva M.G., J. Med. Genet. 40:733-740(2003).Nakamura N., J. Biol. Chem. 280:1561-1572(2005).Bechtel S., BMC Genomics 8:399-399(2007).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human SLC9A9.
Involvement In Disease
Autism 16 (AUTS16)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
May act in electroneutral exchange of protons for Na+ across membranes. Involved in the effusion of Golgi luminal H+ in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.
De Silva M.G., J. Med. Genet. 40:733-740(2003). Nakamura N., J. Biol. Chem. 280:1561-1572(2005). Bechtel S., BMC Genomics 8:399-399(2007).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total SLC9A9 protein.
Subcellular Location
Late endosome membrane, Multi-pass membrane protein
May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.
Protein Families
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
Tissue Specificity
Ubiquitously expressed in all tissues tested. Expressed at highest levels in heart and skeletal muscle, followed by placenta, kidney, and liver. Expressed in the brain, in the medulla and spinal cord.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.