L-type amino acid transporter 3; LAT3; large neutral amino acids transporter small subunit 3; prostate cancer overexpressed gene 1 protein; solute carrier family 43 member 1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.Cole K.A., Genomics 51:282-287(1998).Babu E., J. Biol. Chem. 278:43838-43845(2003).Chuaqui R.F., Urology 50:302-307(1997).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human LAT3.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.
Cole K.A., Genomics 51:282-287(1998). Babu E., J. Biol. Chem. 278:43838-43845(2003). Chuaqui R.F., Urology 50:302-307(1997).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total LAT3 protein.
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.
Protein Families
SLC43A transporter (TC 2.A.1.44) family
Tissue Specificity
In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.