Mitochondrial 2-oxoglutarate/malate carrier protein; OGCP; Solute carrier family 25 member 11;
Categories
Primary Antibodies
Clonality
polyclonal
Description
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.Iacobazzi V., DNA Seq. 3:79-88(1992).Yu W., Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.Colinge J., Submitted (OCT-2008) to UniProtKB.
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human SLC25A11.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.
Iacobazzi V., DNA Seq. 3:79-88(1992). Yu W., Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases. Colinge J., Submitted (OCT-2008) to UniProtKB.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total SLC25A11 protein.
Subcellular Location
Mitochondrion inner membrane, Multi-pass membrane protein
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae
Protein Families
Mitochondrial carrier (TC 2.A.29) family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.