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Home / Antibodies

SKP2/p45 Antibody

SKU : BHA12902967

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AFFINITY BIOSCIENCES LTD

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Mfr.No.	AF0505
Alternative Names	CDK2/Cyclin A associated protein p45 ; Cyclin A/CDK2 associated protein p45 ; Cyclin-A/CDK2-associated protein p45 ; F box protein Skp2 ; F box/LRR repeat protein 1 ; F-box protein Skp2 ; F-box/LRR-repeat protein 1 ; FBL 1 ; FBL1 ; FBXL 1 ; FBXL1 ; FLB 1 ; FLB1 ; MGC1366 ; p45 ; p45skp2 ; S phase kinase associated protein 2 (p45) ; S phase kinase associated protein 2 ; S-phase kinase-associated protein 2 ; S-phase kinase-associated protein 2 E3 ubiquitin protein ligase ; SKP 2 ; Skp2 ; SKP2_HUMAN ;
Categories	Primary Antibodies
Clonality	polyclonal
Description	SKP2 an F-box protein of the SCF (SKP1-CUL1-F- box protein) E3 ubiquitin ligase system. The F-box component of the SCF complex is responsible for recognizing different substrates for ubiquitination. The SCF E3 complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Three alternatively-spliced isoforms have been described.
Immunogen	A synthesized peptide derived from human SKP2/p45.
Molecular Weight	Observed Mol.Wt.: 47kDa. Predicted Mol.Wt.: 48kDa.
Reactivity	Human, Mouse
Specificity	SKP2/p45 Antibody detects endogenous levels of SKP2/p45.
Subcellular Location	Nucleus;

Uniprot

Q13309

Gene Id

6502

Sequence

10	20	30	40	50
MHRKHLQEIP	DLSSNVATSF	TWGWDSSKTS	ELLSGMGVSA	LEKEEPDSEN
60	70	80	90	100
IPQELLSNLG	HPESPPRKRL	KSKGSDKDFV	IVRRPKLNRE	NFPGVSWDSL
110	120	130	140	150
PDELLLGIFS	CLCLPELLKV	SGVCKRWYRL	ASDESLWQTL	DLTGKNLHPD
160	170	180	190	200
VTGRLLSQGV	IAFRCPRSFM	DQPLAEHFSP	FRVQHMDLSN	SVIEVSTLHG
210	220	230	240	250
ILSQCSKLQN	LSLEGLRLSD	PIVNTLAKNS	NLVRLNLSGC	SGFSEFALQT
260	270	280	290	300
LLSSCSRLDE	LNLSWCFDFT	EKHVQVAVAH	VSETITQLNL	SGYRKNLQKS
310	320	330	340	350
DLSTLVRRCP	NLVHLDLSDS	VMLKNDCFQE	FFQLNYLQHL	SLSRCYDIIP
360	370	380	390	400
ETLLELGEIP	TLKTLQVFGI	VPDGTLQLLK	EALPHLQINC	SHFTTIARPT
410	420
IGNKKNQEIW	GIKCRLTLQK	PSCL

Concentration	1mg/ml
Format	Liquid
Purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Applications	IF/ICC, ELISA, IHC, WB
Dilution	WB 1:500-1:2000 IHC 1:50-1:200 IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Manual
MSDS
IHC Protocol.
Western Blotting Handbook.

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SKU	Supplier No.	Size	Your price	Quantity
BHA12902967	AF0505	100ul	$280		Add to Cart
BHA12902967	AF0505	200ul	$350		Add to Cart

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