Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.Kharitonenkov A., Nature 386:181-186(1997).Ota T., Nat. Genet. 36:40-45(2004).Deloukas P., Nature 414:865-871(2001).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human SIRPB1.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.
Kharitonenkov A., Nature 386:181-186(1997). Ota T., Nat. Genet. 36:40-45(2004). Deloukas P., Nature 414:865-871(2001).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total SIRPB1 protein.
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.
Tissue Specificity
Detected in monocytes and dendritic cells.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.