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Home / Antibodies

SHP2 Antibody (R30959)

SKU : BHA17104490

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NSJ Bioreagents

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Mfr.No.	R30959
Clonality	Polyclonal
Description	PTPN11 (Tyrosine-protein phosphatase non-receptor type 11), also known as 'SH2 domain containing protein tyrosine phosphatase 2' (SHP2), is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. The open reading frame consists of 1,779 nucleotides potentially encoding a protein of 593 amino acids with a predicted molecular mass of 68 kD. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP/SHP2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndromeas well as acute myeloid leukemia.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the C-terminus of human SHP2 (RVYENVGLMQQQKSFR) was used as the immunogen for this SHP2 antibody.
Isotype	IgG
Predicted Reactivity	Human, Mouse, Rat
Reactivity	Human, Mouse, Rat
Recombinant	No

Uniprot	Q06124

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the SHP2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB
Dilution	Weste blot: 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104490	R30959	100 ug	$419		Add to Cart

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