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Home / Antibodies

SHB Antibody

SKU : BHA10558680

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA125145
Alternative Names	SH2 domain-containing adapter protein B; SHB;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.Welsh M., Oncogene 9:19-27(1994).Humphray S.J., Nature 429:369-374(2004).Mural R.J., Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human SHB.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. Welsh M., Oncogene 9:19-27(1994). Humphray S.J., Nature 429:369-374(2004). Mural R.J., Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total SHB protein.
Subcellular Location	Cytoplasm, Cell membrane, Peripheral membrane protein, Cytoplasmic side

Uniprot	Q15464
Database Links	HGNC:10838 OMIM:600314 KEGG:hsa:6461 STRING:9606.ENSP00000366936 UniGene:Hs.521482
Function	Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Tissue Specificity	Widely expressed.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558680	CSB-PA125145	100ul	$297		Add to Cart

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