Mouse Anti-Rat SHANK1/SHANK3 Monoclonal IgG2a

Mfr.No.	SMC-460, SMC-460D, SMC-460D-A390, SMC-460D-A488, SMC-460D-A594, SMC-460D-ALP, SMC-460D-APC, SMC-460D-BI, SMC-460D-FITC, SMC-460D-HRP, SMC-460D-PCP, SMC-460D-RPE, SMC-460S
Immunogen Species	Rat
Alternative Names	Shank postsynaptic density protein Antibody, SH3 and multiple ankyrin repeat domains 3 Antibody, Proline rich synapse associated protein 2 Antibody, Proline-rich synapse-associated protein 2 Antibody, ProSAP2 Antibody, PSAP2 Antibody, Antibody, SH3 and multiple ankyrin repeat domains protein 3 Antibody, SH3/ankyrin domain gene 3,Shank3b Antibody, SPANK 2 Antibody, SPANK2 Antibody, KAP/SAPAP interacting protein Antibody, OTTHUMP00000174437 Antibody, SH3 and multiple ankyrin repeat domains 1 Antibody, SH3 and multiple ankyrin repeat domains protein 1 Antibody, SH3/ankyrin domain gene 1 Antibody, SHANK 1 Antibody, Shank1 Antibody, Shank1a Antibody, Somatostatin receptor interacting protein Antibody, Somatostatin receptor-interacting protein Antibody, SPANK 1 Antibody, SPANK1 Antibody, SSTR interacting protein Antibody, SSTR-interacting protein Antibody, SSTRIP Antibody, Synamon Antibody, AI841104 Antibody, DEL22q13.3 Antibody, KIAA1650 Antibody
Categories	Antibodies
Cellular Localization	Cytoplasm, Cell Junction
Certificate Of Analysis	1 ug/ml of SMC-460 was sufficient for detection of SHANK1/SHANK3 in 20 ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Rat SHANK1/SHANK3 Monoclonal IgG2a
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3. Mouse: 100% identity (89/89 amino acids identical). Human: 97% identity (87/89 amino acids identical). ~70% identity with SHANK1 and SHANK2., Rattus Norvegicus (Rat)
Immunogen Region	Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3. Mouse: 100% identity (89/89 amino acids identical). Human: 97% identity (87/89 amino acids identical). ~70% identity with SHANK1 and SHANK2.
Isotype	IgG2a
Launch Date	2013/10/29
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Rattus Norvegicus (Rat)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	Q9JLU4
Accession Number	NP_067708.1.
Gene Id	59312
Target	SHANK3
Clone No	S367-51
Research Area	Cell Markers, Neuron Markers, Postsynaptic Markers, Cell Signaling, Scaffold Proteins, Neuroscience

Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	SHANK proteins are scaffolding adaptors that have been shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. SHANK1-3 of the SHANK/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). SHANK recruits betaPIX and PAK to dendritic spines to regulate postsynaptic structure and interacts with ionotropic receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~190kDa. Cross-reacts with SHANK1. Does not cross-react with SHANK2.
Storage	-20ºC
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11904609-1	SMC-460D	Unconjugated	100 ug	$330	Add to Cart
BHA11904609-2	SMC-460D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11904609-3	SMC-460D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11904609-4	SMC-460D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11904609-5	SMC-460D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11904609-6	SMC-460D-APC	APC	100 ug	$382	Add to Cart
BHA11904609-7	SMC-460D-BI	Biotin	100 ug	$378	Add to Cart
BHA11904609-8	SMC-460D-FITC	FITC	100 ug	$374	Add to Cart
BHA11904609-9	SMC-460D-HRP	HRP	100 ug	$370	Add to Cart
BHA11904609-10	SMC-460D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11904609-11	SMC-460D-RPE	RPE	100 ug	$380	Add to Cart
BHA11904609-12	SMC-460S	Unconjugated	12 ug	$44	Add to Cart

SHANK1/SHANK3 Antibody, Clone S367-51 - SMC-460

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