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Home / Primary Antibodies / Monoclonal Antibodies

SHANK1 Antibody, Clone N22/21 - SMC-329

BHA11902956
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+1 866.986.9598
Email
[email protected]
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Swissprot Q9WV48
Accession Number NP_113939.2
Gene Id 78957
Target SHANK1
Clone No N22/21
Research Area Cell Markers, Neuron Markers, Postsynaptic Markers, Cell Signaling, Scaffold Proteins, Neuroscience
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, IHC, WB
Description WB ; IHC ; AM
Dilution WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Sheng M., and Kim E. (2000) Journal of Cell Science. 113: 1851-1856.

2. Kim J.H., et al. (2009) Exp Mol Med. 41(4): 236-242.

3. Gong Y., et al. (2009) Brain Res. 1292: 191-198.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11902956-1 SMC-329D Unconjugated 100 ug $330
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BHA11902956-2 SMC-329D-A390 ATTO 390 100 ug $384
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BHA11902956-3 SMC-329D-A488 ATTO 488 100 ug $383
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BHA11902956-4 SMC-329D-A594 ATTO 594 100 ug $383
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BHA11902956-5 SMC-329D-ALP Alkaline Phosphatase 100 ug $376
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BHA11902956-6 SMC-329D-APC APC 100 ug $382
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BHA11902956-7 SMC-329D-BI Biotin 100 ug $378
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BHA11902956-8 SMC-329D-FITC FITC 100 ug $374
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BHA11902956-9 SMC-329D-HRP HRP 100 ug $370
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BHA11902956-10 SMC-329D-PCP PerCP 100 ug $382
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BHA11902956-11 SMC-329D-RPE RPE 100 ug $380
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BHA11902956-12 SMC-329S Unconjugated 12 ug $44
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