Splicing factor; arginine/serine-rich 8; Suppressor of white apricot protein homolog; SFRS8; SWAP
Categories
Primary Antibodies
Clonality
polyclonal
Description
Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10.Denhez F., J. Biol. Chem. 269:16170-16179(1994).Scherer S.E., Nature 440:346-351(2006).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human SFRS8.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10.
Denhez F., J. Biol. Chem. 269:16170-16179(1994). Scherer S.E., Nature 440:346-351(2006).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total SFRS8 protein.
Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.