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Home / Antibodies

SERBP1 Antibody / PAI-RBP1 (V7558SAF)

SKU : BHA17126689

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NSJ Bioreagents

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Mfr.No.	V7558SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	PAI-RBP1 (plasminogen activator inhibitor 1 RNA-binding protein), also known as SERBP1 (SERPINE1 mRNA-binding protein 1), CGI-55, CHD3IP (chromodomain helicase DNA binding protein 3 interacting protein), HABP4L or PAI-RBP1, is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. PAI-RBP1 is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, PAI-RBP1 interacts with Mi2-alpha and may be involved in chromatin remodeling. PAI-RBP1 also interacts with PGRMC1 and participates in the transduction of Progesterone's antiapoptotic action in ovarian cell types. The gene encoding PAI-RBP1 is overexpressed in ovarian cancer, suggesting a possible role for PAI-RBP1 in tumorigenesis and tumor metastasis.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	A recombinant human partial protein corresponding to amino acids 3-139 was used as the immunogen for the SERBP1 antibody.
Isotype	Mouse IgG1, kappa
Species Reactivity	Human
Note	Optimal dilution of the SERBP1 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Uniprot	Q8NC51

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the SERBP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IHC-P, WB
Description	Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT (1),Weste blot: 1-2ug/ml

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/serbp1-antibody-serbp1-3491-protein-microarray-validated-v7558" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17126689	V7558SAF-100UG	100 ug	$499		Add to Cart

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