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Home / Primary Antibodies / Polyclonal Antibodies

SACS Rabbit pAb

SKU : BHA15210444

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ELK Biotechnology

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Mfr.No.	ES11443
Antigen	SACS
Background	SACS encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. SACS is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. SACS includes a very large exon spanning more than 12. kb. Mutations in SACS result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that "the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins" (Parfitt et al. PubMed: 19208651). A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants.
Clonality	Polyclonal
Conjugate	Unconjugate
Host	Rabbit
Immunogen	Synthesized peptide derived from human protein . at AA range? 4291-4340
Isotype	IgG
Reactivity	Human, Mouse

Gene Id	26278

Concentration	1mg/ml
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Applications	IHC

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA15210444	ES11443	50µl	$148		Add to Cart
BHA15210444	ES11443	100µl	$248		Add to Cart

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