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Home / Antibodies

RUNX1 (Ab-435) Antibody

SKU : BHA10559149

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA132524
Alternative Names	Acute myeloid leukemia 1 protein; CBF-alpha 2; CBFA2; Core-binding factor; alpha 2 subunit
Categories	Primary Antibodies
Clonality	polyclonal
Description	CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation.Miyoshi H., Proc. Natl. Acad. Sci. U.S.A. 88:10431-10434(1991).Sacchi N., Genes Chromosomes Cancer 11:226-236(1994).Nucifora G., Blood 81:2728-2734(1993).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human AML1 around the phosphorylation site of serine 435 (S-N-S(p)-P-T).
Involvement In Disease	Familial platelet disorder with associated myeloid malignancy (FPDMM)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Miyoshi H., Proc. Natl. Acad. Sci. U.S.A. 88:10431-10434(1991). Sacchi N., Genes Chromosomes Cancer 11:226-236(1994). Nucifora G., Blood 81:2728-2734(1993).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total AML1 protein.
Subcellular Location	Nucleus

Uniprot	Q01196
Gene Id	861
Database Links	HGNC:10471 OMIM:151385 KEGG:hsa:861 STRING:9606.ENSP00000300305 UniGene:Hs.149261
Function	CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells
Pathway	Th17 cell differentiation
Tissue Specificity	Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
Weight	37,733 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559149	CSB-PA132524	100ul	$297		Add to Cart

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