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Home / Primary Antibodies

RRAGA/RRAGB Antibody

SKU : BHA10558625

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA590465
Alternative Names	Ras-related GTP-binding protein A; Rag A; RagA; Adenovirus E3 14.7 kDa-interacting protein 1; FIP-1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.Schuermann A., J. Biol. Chem. 270:28982-28988(1995).Li Y., J. Virol. 71:1576-1582(1997).Hirose E., J. Cell Sci. 111:11-21(1998).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human RRAGA/B.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Schuermann A., J. Biol. Chem. 270:28982-28988(1995). Li Y., J. Virol. 71:1576-1582(1997). Hirose E., J. Cell Sci. 111:11-21(1998).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total RRAGA/B protein.
Subcellular Location	Cytoplasm, Nucleus, Lysosome

Uniprot	Q7L523
Database Links	HGNC:16963 OMIM:612194 KEGG:hsa:10670 STRING:9606.ENSP00000369899 UniGene:Hs.743260
Function	Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Pathway	mTOR signaling pathway Autophagy
Protein Families	GTR/RAG GTP-binding protein family
Tissue Specificity	Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558625	CSB-PA590465	100ul	$297		Add to Cart

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