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Home / Primary Antibodies

RPS6KA5 (Ab-376) Antibody

SKU : BHA10557613

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA144527
Alternative Names	MSPK1; RPS6KA5;
Categories	Primary Antibodies
Clonality	polyclonal, polyclonal
Description	Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).Roux PP, et al. (2004) Microbiol Mol Biol Rev. Jun; 68(2): 320-344McCOY C, et al. (2005) Biochem J. Apr 15; 387(Pt 2): 507-517
Host	Rabbit
Immunogen	Peptide sequence around aa.374~378 (G-Y-S-F-V) derived from Human MSK1., Peptide sequence around aa.374~378 (G-Y-S-F-V) derived from Human MSK1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat, Rat
Regulatory	RUO
Relevance	Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). Roux PP, et al. (2004) Microbiol Mol Biol Rev. Jun; 68(2): 320-344 McCOY C, et al. (2005) Biochem J. Apr 15; 387(Pt 2): 507-517
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total MSK1 protein.
Subcellular Location	Nucleus, Cytoplasm

Uniprot	O75582
Database Links	HGNC:10434 OMIM:603607 KEGG:hsa:9252 STRING:9606.ENSP00000261991 UniGene:Hs.510225
Function	Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes
Pathway	MAPK signaling pathway TNF signaling pathway MAPK Erk pathway Neurotrophin signaling pathway, MAPK signaling pathway TNF signaling pathway MAPK Erk pathway Neurotrophin signaling pathway
Protein Families	Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
Tissue Specificity	Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol., Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557613	CSB-PA144527	100ul	$297		Add to Cart

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