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Home / Primary Antibodies / Polyclonal Antibodies

ROR2 Antibody (pTyr645 + pTyr646) - SPC-1075

BHA11914166
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
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Swissprot Q01974
Accession Number NP_004551
Gene Id 4920
Target ROR2 (pTyr645 + pTyr646)
Research Area Cell Signaling, Protein Phosphorylation, Tyrosine Kinases, Receptor Tyrosine Kinases, Extracellular Matrix (ECM), Bone, Stem Cells, Mesenchymal Stem Cells, Osteogenesis
Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions WB (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Highly expressed during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
Scientific Background ROR2 is a receptor tyrosine kinase which may have a role in early cartilage and growth plate development. ROR2 expression is generally highest during embryonic development and will gradually decrease as cells terminally differentiate. Wnt5a has been identified to utilize ROR2 as a co-receptor for non-canonical Wnt signalling. Aberrant expression of ROR2 has been implicated in gastric, osteosarcoma, mestatic melanoma, prostate, renal cell and squamous cell carcinomas. Increased expression of ROR2 was correlated with increased metastasis. In prostate, osteosarcomas and metastatic melanomas, Wnt5a/ROR2 receptor complex formation was implicated as the mechanism for cancer progression. ROR2 seems to function as an oncogene. Primarily mis-sense mutations of ROR2 have been identified in tumours but their functional effect has not been well characterized.
Shipping Temperature Blue Ice or 4°C
Specificity Detects 104.757 kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, WB
Description WB ; AM
Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11914166-1 SPC-1075D Unconjugated 100 ul $331
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BHA11914166-2 SPC-1075D-A390 ATTO 390 100 ul $385
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BHA11914166-3 SPC-1075D-A488 ATTO 488 100 ul $384
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BHA11914166-4 SPC-1075D-A594 ATTO 594 100 ul $384
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BHA11914166-5 SPC-1075D-BI Biotin 100 ul $380
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BHA11914166-6 SPC-1075D-FITC FITC 100 ul $375
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