Rho-related BTB domain-containing protein 2; Deleted in breast cancer 2 gene protein;
Categories
Primary Antibodies
Clonality
polyclonal
Description
The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene.Ramos S., Gene 298:147-157(2002).Nagase T., DNA Res. 5:277-286(1998).Nakajima D., DNA Res. 9:99-106(2002).
Host
Rabbit
Immunogen
Synthesized peptide derived from inteal of Human RHBT2.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene.
Ramos S., Gene 298:147-157(2002). Nagase T., DNA Res. 5:277-286(1998). Nakajima D., DNA Res. 9:99-106(2002).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total RHBT2 protein.