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Home / Primary Antibodies

RFWD3 Antibody

SKU : BHA10558655

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA041555
Alternative Names	MLKL; ring finger and WD repeat domain 3; RING finger protein 201; RNF201;
Categories	Primary Antibodies
Clonality	polyclonal
Description	E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.The MGC Project Team, Genome Res. 14:2121-2127(2004).Ota T., Nat. Genet. 36:40-45(2004).Matsuoka S., Science 316:1160-1166(2007).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human RFWD3.
Involvement In Disease	Fanconi anemia, complementation group W (FANCW): A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair (PubMed:28575657). The disease is caused by mutations affecting the gene represented in this entry.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair. The MGC Project Team, Genome Res. 14:2121-2127(2004). Ota T., Nat. Genet. 36:40-45(2004). Matsuoka S., Science 316:1160-1166(2007).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total RFWD3 protein.
Subcellular Location	Nucleus, Nucleus, PML body, Cytoplasm

Uniprot	Q6PCD5
Database Links	HGNC:25539 OMIM:614151 KEGG:hsa:55159 STRING:9606.ENSP00000354361 UniGene:Hs.567525
Function	E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558655	CSB-PA041555	100ul	$297		Add to Cart

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