Renalase is a 342 amino acid FAD-dependent amine oxidase that is highly expressed in kidney and is expressed at a lower level in heart, skeletal muscle and small intestine. Renalase is secreted in the blood by the kidney and it is thought to regulate cardiac function and systemic blood pressure. It is also suggested that Renalase functions as a hormone that metabolizes circulating catecholamines, which have an active role in the sympathetic and parasympathetic nervous systems. Individuals with chronic kidney disease and end-stage renal disease have markedly reduced levels of plasma Renalase than healthy individuals. Infusion of Renalase in animal models causes decrease in heart rate, cardiac contractility and blood pressure. Two isoforms of Renalase exist due to alteative splicing events.
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
A portion of amino acids 34-235 from the human protein was used as the immunogen for the Renalase antibody.
Isotype
Mouse IgG2b, kappa
Species Reactivity
Human
Note
Optimal dilution of the Renalase antibody should be determined by the researcher.
Uniprot
Q5VYX0
Format
Purified
Purity
Protein G affinity
Storage
Store the Renalase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Applications
ELISA
Description
ELISA (order BSA/sodium azide-free format for coating)