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Home / Antibodies

RAD50 Antibody

SKU : BHA10558150

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA589951
Alternative Names	DNA repair protein RAD50; EC 3.6.-.-; hRAD50;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.Dolganov G.M., Mol. Cell. Biol. 16:4832-4841(1996).Kim K.K., Gene 235:59-67(1999).Carney J.P., Cell 93:477-486(1998).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human RAD50.
Involvement In Disease	Nijmegen breakage syndrome-like disorder (NBSLD)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. Dolganov G.M., Mol. Cell. Biol. 16:4832-4841(1996). Kim K.K., Gene 235:59-67(1999). Carney J.P., Cell 93:477-486(1998).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total RAD50 protein.
Subcellular Location	Nucleus, Chromosome, telomere

Uniprot	Q92878
Database Links	HGNC:9816 OMIM:604040 KEGG:hsa:10111 STRING:9606.ENSP00000265335 UniGene:Hs.633509
Function	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point
Pathway	Cellular senescence
Protein Families	SMC family, RAD50 subfamily
Tissue Specificity	Expressed at very low level in most tissues, except in testis where it is expressed at higher level. Expressed in fibroblasts.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558150	CSB-PA589951	100ul	$297		Add to Cart

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