Reacts with viral glycoprotein of rabies virus strains SAD-Vnukovo and Pitman-Moore. This mAb is useful in detecting rabies virus by ELISA and Weste. It is capable of neutralizing rabies virus. Rabies virus (Neurotropic virus) is a member of the Rhabdoviridae family. Rabies is a single stranded, neurotropic, negative sense RNA virus which encodes 5 proteins: a glycoprotein, a nucleoprotein, and three others. The mature virus has a bullet shape, a protein coat, and a lipid envelope. The outer surface of the virus is covered with thumb like glycoprotein projections 5-10 nm long and 3 nm in diameter. The virus averages approximately 780 nm in length. Lipid solvents destroy virus infectivity. Rabies virus is a very successful virus, with a very wide range of hosts. It causes an acute, central nervous system infection, characterized by CNS irritation, followed by paralysis and death. Approximately 50,000 human deaths each year are caused by rabies.
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
Purified virions of SAD-Vnukovo strain followed by Pitman-Moore strain was used as the immunogen for the Rabies Virus antibody.
Isotype
Mouse IgG2b, kappa
Species Reactivity
Rabies Virus of strains SAD-Vnukovo and Pitman Moore
Note
Optimal dilution of the Rabies Virus antibody should be determined by the researcher.
Uniprot
Not Applicable
Format
Purified
Purity
Protein G affinity chromatography
Storage
Store the Rabies Virus antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Applications
ELISA, ICC, IF
Description
ELISA (order BSA/sodium azide-free format for coating),Immunocytochemistry (Acetone-fixed frozen): 0.5-1ug/ml for 30 min,Immunofluorescence: 0.5-1ug/ml