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Home / Primary Antibodies / Polyclonal Antibodies

Rabbit Anti-Human Truncated Tau Fragment (AA297-391) (dGAE) Polyclonal

SKU : BHA11933457

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StressMarq Biosciences Inc.

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Mfr.No.	SPC-806
Alternative Names	Tau Antibody, Neurofibrillary tangle protein Antibody, MAPTL Antibody, Microtubule-associated protein tau Antibody, MTBT1 Antibody, Paired helical filament-tau Antibody, TAU Antibody, PHF-tau Antibody, MAPT Antibody, AI413597 antibody, AW045860 antibody, DDPAC antibody, FLJ31424 antibody, FTDP 17 antibody, G protein beta1/gamma2 subunit interacting factor 1 antibody, MAPT antibody, MAPTL antibody, MGC134287 antibody, MGC138549 antibody, MGC156663 antibody, Microtubule associated protein tau antibody, Microtubule associated protein tau isoform 4 antibody, Microtubule-associated protein tau antibody, MSTD antibody, Mtapt antibody, MTBT1 antibody, MTBT2 antibody, Neurofibrillary tangle protein antibody, Paired helical filament tau antibody, Paired helical filament-tau antibody, PHF tau antibody, PPND antibody, PPP1R103 antibody, Protein phosphatase 1, regulatory subunit 103 antibody, RNPTAU antibody, TAU antibody, TAU_HUMAN antibody, Tauopathy and respiratory failure, included antibody, dGAE tau fibril antibody, Truncated Tau Fragment (AA297-391) antibody, 95-amino acid tau protein fragment antibody, Truncated Tau Protein antibody
Categories	Antibodies
Cellular Localization	Cell membrane, Cytoskeleton, Growth cone, Peripheral membrane protein, Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytosol, Dendrite, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Plasma Membrane, Tubulin Complex
Certificate Of Analysis	A 1:1000 dilution of SPC-806 was sufficient for detection of tau in 15 ?g of mouse, rat brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human Truncated Tau Fragment (AA297-391) (dGAE) Polyclonal
Host	Rabbit
Immunogen Region	Recombinant Human Tau AA297-391 (dGAE) Fibril (SPR-461)
Reactivity	Human, Mouse, Rat

Swissprot	P10636
Accession Number	NP_005901.2
Gene Id	4137

Buffer	PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide
Concentration	1 mg/mL
Purification	Protein A
Scientific Background	Alzheimers Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing paired helical filaments (PHFs). A truncated 95-amino acid fragment corresponding to residues 297-391 of full-length tau has been shown to assemble into PHF-like fibrils in vitro in the absence of additives or templates (3). This fragment has been found in the core of PHFs from AD brains and forms filaments that closely resemble PHFs isolated from AD brains (3).
Shipping Temperature	Blue Ice or 4ÂºC
Specificity	Detects ~10.2 kDa.
Storage	-20ÂºC

Applications	WB
Dilution	WB (1:1000)

Reference	1. www.alz.org/alzheimers-dementia/facts-figures2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146148 (1907)3. Al-Hilaly, Y.K. et al. Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking. J. Mol. Biol. 429(23):3650-3665 (2017)

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Combination SKU	Supplier No.	Conjugate	Size	Your price	Quantity
BHA11933457-1	SPC-806D	Unconjugated	100ug	$330		Add to Cart
BHA11933457-2	SPC-806D-A390	ATTO 390	100ug	$384		Add to Cart
BHA11933457-3	SPC-806D-A488	ATTO 488	100ug	$383		Add to Cart
BHA11933457-4	SPC-806D-A594	ATTO 594	100ug	$383		Add to Cart
BHA11933457-5	SPC-806D-ALP	Alkaline Phosphatase	100ug	$376		Add to Cart
BHA11933457-6	SPC-806D-APC	APC	100ug	$382		Add to Cart
BHA11933457-7	SPC-806D-BI	Biotin	100ug	$378		Add to Cart
BHA11933457-8	SPC-806D-FITC	FITC	100ug	$374		Add to Cart
BHA11933457-9	SPC-806D-HRP	HRP	100ug	$370		Add to Cart
BHA11933457-10	SPC-806D-PCP	PerCP	100ug	$382		Add to Cart
BHA11933457-11	SPC-806D-RPE	RPE	100ug	$380		Add to Cart

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