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Home / Antibodies

RAB5A Antibody

SKU : BHA10557577

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA280354
Alternative Names	RAB5A
Categories	Primary Antibodies
Clonality	polyclonal
Description	Required for the fusion of plasma membranes and early endosomes.Callaghan J.M., Nixon S., Bucci C., Toh B.-H., Stenmark H.Eur. J. Biochem. 265:361-366(1999) Hoffenberg S., Liu X., Nikolova L., Hall H.S., Dai W., Baughn R.E., Dickey B.F., Barbieri M.A., Aballay A., Stahl P.D., Knoll B.J.J. Biol. Chem. 275:24661-24669(2000)
Host	Rabbit
Immunogen	Peptide sequence around aa.188~192( N-P-G-A-N) derived from Human Rab5.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Required for the fusion of plasma membranes and early endosomes. Callaghan J.M., Nixon S., Bucci C., Toh B.-H., Stenmark H.Eur. J. Biochem. 265:361-366(1999) Hoffenberg S., Liu X., Nikolova L., Hall H.S., Dai W., Baughn R.E., Dickey B.F., Barbieri M.A., Aballay A., Stahl P.D., Knoll B.J.J. Biol. Chem. 275:24661-24669(2000)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total Rab5 protein.
Subcellular Location	Cell membrane, Lipid-anchor, Cytoplasmic side, Early endosome membrane, Lipid-anchor, Melanosome, Cytoplasmic vesicle, Cell projection, ruffle, Membrane, Cytoplasm, cytosol, Cytoplasmic vesicle, phagosome membrane, Endosome membrane

Uniprot	P20339
Database Links	HGNC:9783 OMIM:179512 KEGG:hsa:5868 STRING:9606.ENSP00000273047 UniGene:Hs.475663
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes
Pathway	Ras signaling pathway Endocytosis Secreted Extracellular Vesicles
Protein Families	Small GTPase superfamily, Rab family

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557577	CSB-PA280354	100ul	$297		Add to Cart

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