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Home / Antibodies

RAB13 Antibody (F53816)

SKU : BHA17102427

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Mfr.No.	F53816, F53816-0.05ML, F53816-0.2ML
Antigen	RAB13
Clonality	Monoclonal
Description	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin- induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Mouse
Immunogen Region	A human recombinant protein corresponding to amino acids 1-203 was used as the immunogen for the RAB13 antibody.
Isotype	IgG1
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	P51153
Gene Id	5872
Clone No	1600CT845.37.29

Format	Purified
Purification	Protein G affinity chromatography
Storage	Aliquot the RAB13 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB
Dilution	Western blot: 1:500-1000

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17102427-1	F53816-0.05ML	0.05ml	$165		Add to Cart
BHA17102427-2	F53816-0.2ML	0.2ml	$389		Add to Cart

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