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Home / Primary Antibodies

PTPN22 Antibody

SKU : BHA10558739

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA780242
Alternative Names	Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LyP; LYP1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.Cohen S., Blood 93:2013-2024(1999).Liu T., Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.Wang S., Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human PTPN22.
Involvement In Disease	Systemic lupus erythematosus (SLE); Diabetes mellitus, insulin-dependent (IDDM); Rheumatoid arthritis (RA); Vitiligo (VTLG)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Cohen S., Blood 93:2013-2024(1999). Liu T., Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases. Wang S., Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PTPN22 protein.
Subcellular Location	Cytoplasm

Uniprot	Q9Y2R2
Database Links	HGNC:9652 OMIM:152700 KEGG:hsa:26191 STRING:9606.ENSP00000352833 UniGene:Hs.535276
Function	Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules
Protein Families	Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily
Tissue Specificity	Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and bo

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558739	CSB-PA780242	100ul	$297		Add to Cart

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