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Home / Antibodies

PTEN Antibody (phospho-Y176) (F48804)

SKU : BHA17101378

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NSJ Bioreagents

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Mfr.No.	F48804, F48804-0.08ML, F48804-0.4ML
Antigen	Phospho-PTEN
Clonality	Polyclonal
Description	This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	This phospho-PTEN antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY176 of human PTEN.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	P60484

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the phospho-PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	DB, ELISA
Dilution	Dot blot: 1:500

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17101378-1	F48804-0.08ML	0.08ml	$165		Add to Cart
BHA17101378-2	F48804-0.4ML	0.4ml	$379		Add to Cart

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