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Home / Antibodies

PSMD11 Antibody

SKU : BHA10558155

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA093833
Alternative Names	26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit p44.5; 26S proteasome regulatory subunit S9; PSD11;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.Hoffman L., FEBS Lett. 404:179-184(1997).Saito A., Gene 203:241-250(1997).The MGC Project Team; Genome Res. 14:2121-2127(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human PSMD11.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Hoffman L., FEBS Lett. 404:179-184(1997). Saito A., Gene 203:241-250(1997). The MGC Project Team; Genome Res. 14:2121-2127(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PSMD11 protein.
Subcellular Location	Nucleus, Cytoplasm, cytosol

Uniprot	O00231
Database Links	HGNC:9556 OMIM:604449 KEGG:hsa:5717 STRING:9606.ENSP00000261712 UniGene:Hs.443379
Function	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs)
Protein Families	Proteasome subunit S9 family
Tissue Specificity	Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558155	CSB-PA093833	100ul	$297		Add to Cart

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