Mouse Anti-Mouse Protocadherin Gamma (pan) Monoclonal IgG1

Mfr.No.	SMC-454, SMC-454D, SMC-454D-A390, SMC-454D-A488, SMC-454D-A594, SMC-454D-ALP, SMC-454D-APC, SMC-454D-BI, SMC-454D-FITC, SMC-454D-HRP, SMC-454D-PCP, SMC-454D-RPE, SMC-454S
Immunogen Species	Mouse
Alternative Names	PCDH gamma A Antibody, PCDH-gamma-A Antibody, PCDHGA Antibody, Protocadherin gamma A Antibody, Protocadherin gamma subfamily A Antibody, Gamma Protocadherin A (pan) Antibody, Pan-Gamma-Protocadherin-A Antibody, Pan Gamma Protocadherin A Antibody
Categories	Antibodies
Cellular Localization	Cell Membrane
Certificate Of Analysis	1 ug/ml of SMC-454 was sufficient for detection of Protocadherin gamma (pan) in 20 ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Mouse Protocadherin Gamma (pan) Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Protocadherin-gamma-A1 that is shared by all 22 Gamma-protocadherins (A subfamily amino acids ~807-930, B subfamily amino acids ~789-912 and C subfamily , Mus Musculus (Mouse), Fusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Protocadherin-gamma-A1 that is shared by all 22 Gamma-protocadherins (A subfamily amino acids ~807-930, B subfamily amino acids ~789-912 and C subfamily , Fusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Protocadherin-gamma-A1 that is shared by all 22 Gamma-protocadherins (A subfamily amino acids ~807-930, B subfamily amino acids ~789-912 and C subfamily
Immunogen Region	Fusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Protocadherin-gamma-A1 that is shared by all 22 Gamma-protocadherins (A subfamily amino acids ~807-930, B subfamily amino acids ~789-912 and C subfamily amino acids ~818-941). 99% identity with human (123/124 amino acids).
Isotype	IgG1
Launch Date	2013/10/29
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Mus Musculus (Mouse)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	Q91XZ0
Accession Number	NP_291062.1
Gene Id	93709
Target	Protocadherin Gamma
Clone No	S159-5
Research Area	Cell Markers, Neuron Markers, Membrane Markers, Neuroscience

Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~100kDa. Cross-reacts with all Gamma-protocadherin-A, -B and -C proteins.
Storage	-20ºC
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11904533-1	SMC-454D	Unconjugated	100 ug	$330	Add to Cart
BHA11904533-2	SMC-454D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11904533-3	SMC-454D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11904533-4	SMC-454D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11904533-5	SMC-454D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11904533-6	SMC-454D-APC	APC	100 ug	$382	Add to Cart
BHA11904533-7	SMC-454D-BI	Biotin	100 ug	$378	Add to Cart
BHA11904533-8	SMC-454D-FITC	FITC	100 ug	$374	Add to Cart
BHA11904533-9	SMC-454D-HRP	HRP	100 ug	$370	Add to Cart
BHA11904533-10	SMC-454D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11904533-11	SMC-454D-RPE	RPE	100 ug	$380	Add to Cart
BHA11904533-12	SMC-454S	Unconjugated	12 ug	$44	Add to Cart

Protocadherin Gamma Antibody, Clone S159-5 - SMC-454

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