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Home / Primary Antibodies

PRLR Antibody

SKU : BHA10557518

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA964526
Alternative Names	hPRLrI
Categories	Primary Antibodies
Clonality	polyclonal
Description	This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signalingBoutin J.M,et al.Mol. Endocrinol. 3:1455-1461(1989)Kline J.B,et al.J. Biol. Chem. 274:35461-35468(1999) Hu Z.Z,et al.J. Clin. Endocrinol. Metab. 84:1153-1156(1999)
Host	Rabbit
Immunogen	Peptide sequence around aa.25~29 (Q-L-P-P-G) derived from Human PRLR
Involvement In Disease	Multiple fibroadenomas of the breast (MFAB); Hyperprolactinemia (HPRL)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling Boutin J.M,et al.Mol. Endocrinol. 3:1455-1461(1989) Kline J.B,et al.J. Biol. Chem. 274:35461-35468(1999) Hu Z.Z,et al.J. Clin. Endocrinol. Metab. 84:1153-1156(1999)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PRLR protein.
Subcellular Location	Membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 7: Secreted

Uniprot	P16471
Database Links	HGNC:9446 OMIM:176761 KEGG:hsa:5618 STRING:9606.ENSP00000371432 UniGene:Hs.368587
Function	This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Pathway	Jak-STAT signaling pathway PI3K-Akt signaling pathway
Protein Families	Type I cytokine receptor family, Type 1 subfamily
Tissue Specificity	Expressed in breast, placenta, kidney, liver and pancreas.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557518	CSB-PA964526	100ul	$297		Add to Cart

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