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Home / Primary Antibodies

PRKG2 (Ab-126) Antibody

SKU : BHA10557683

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA843898
Alternative Names	CGK 2; cGKII; cGMP-dependent protein kinase 2; EC 2.7.11.12; KGP2
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants.Orstavik S., Biochem. Biophys. Res. Commun. 220:759-765(1996).Fujii M., FEBS Lett. 375:263-267(1995).Witczak O., Biochem. Biophys. Res. Commun. 245:113-119(1998).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human PKG2 around the phosphorylation site of serine 126 (G-V-S(p)-A-E).
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. Orstavik S., Biochem. Biophys. Res. Commun. 220:759-765(1996). Fujii M., FEBS Lett. 375:263-267(1995). Witczak O., Biochem. Biophys. Res. Commun. 245:113-119(1998).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PKG2 protein.
Subcellular Location	Apical cell membrane, Lipid-anchor

Uniprot	Q13237
Database Links	HGNC:9416 OMIM:601591 KEGG:hsa:5593 STRING:9606.ENSP00000264399 UniGene:Hs.232044
Function	Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).
Pathway	Gap junction cGMP-PKG signaling pathway
Protein Families	Protein kinase superfamily, AGC Ser/Thr protein kinase family, cGMP subfamily
Tissue Specificity	Highly concentrated in brain, lung and intestinal mucosa.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557683	CSB-PA843898	100ul	$297		Add to Cart

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