cAMP-dependent protein kinase type I-alpha regulatory subunit; Tissue-specific extinguisher 1; TSE1; PRKAR1A; PKR1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.Sandberg M.,, Biochem. Biophys. Res. Commun. 149:939-945(1987).Sandberg M., Biochem. Biophys. Res. Commun. 167:323-330(1990).Jones K.W., Cell 66:861-872(1991).
Host
Rabbit
Immunogen
Synthesized peptide derived from N-terminal of Human KAP0.
Involvement In Disease
Carney complex 1 (CNC1); Intracardiac myxoma (INTMYX); Primary pigmented nodular adrenocortical disease 1 (PPNAD1); Acrodysostosis 1, with or without hormone resistance (ACRDYS1)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Sandberg M.,, Biochem. Biophys. Res. Commun. 149:939-945(1987). Sandberg M., Biochem. Biophys. Res. Commun. 167:323-330(1990). Jones K.W., Cell 66:861-872(1991).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total KAP0 protein.
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Pathway
Insulin signaling pathway
Protein Families
CAMP-dependent kinase regulatory chain family
Tissue Specificity
Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.