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Home / Primary Antibodies

PRKACB Antibody

SKU : BHA10557826

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA987088
Alternative Names	EC 2.7.11.11; KAPB; KAPCB; PKA C-beta; PKA-beta
Categories	Primary Antibodies
Clonality	polyclonal
Description	Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.Beebe S.J., Mol. Endocrinol. 4:465-475(1990).Gregory S.G., Nature 441:315-321(2006).Wu K.-J., Oncogene 21:7872-7882(2002).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human KAPCB.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Beebe S.J., Mol. Endocrinol. 4:465-475(1990). Gregory S.G., Nature 441:315-321(2006). Wu K.-J., Oncogene 21:7872-7882(2002).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total KAPCB protein.
Subcellular Location	Cytoplasm, Cell membrane, Membrane, Lipid-anchor, Nucleus

Uniprot	P22694
Database Links	HGNC:9381 OMIM:176892 KEGG:hsa:5567 STRING:9606.ENSP00000359719 UniGene:Hs.487325
Function	Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis
Pathway	Calcium signaling pathway cAMP signaling pathway Chemokine signaling pathway Estrogen signaling pathway Hedgehog signaling pathway MAPK signaling pathway Melanogenesis Wnt signaling pathway Gap junction Vascular smooth muscle contraction Autophagy Ras signaling pathway Th17 cell differentiation Apelin signaling pathway Glucagon signaling pathway Insulin signaling pathway Glutamatergic synapse
Protein Families	Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
Tissue Specificity	Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557826	CSB-PA987088	100ul	$297		Add to Cart

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