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PPP2R2B Antibody

SKU : BHA10558672

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA168178
Alternative Names	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; PP2A subunit B isoform B55-beta; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A subunit B isoform beta
Categories	Primary Antibodies
Clonality	polyclonal
Description	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity By similarity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance By similarity.Mayer R.E., Biochemistry 30:3589-3597(1991) [PubMed: 1849734].Ota T., Nat. Genet. 36:40-45(2004) [PubMed: 14702039].Schmutz J., Nature 431:268-274(2004) [PubMed: 15372022].
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human PPP2R2B.
Involvement In Disease	Spinocerebellar ataxia 12 (SCA12)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity By similarity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance By similarity. Mayer R.E., Biochemistry 30:3589-3597(1991) [PubMed: 1849734]. Ota T., Nat. Genet. 36:40-45(2004) [PubMed: 14702039]. Schmutz J., Nature 431:268-274(2004) [PubMed: 15372022].
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PPP2R2B protein.
Subcellular Location	Isoform 1: Cytoplasm, Cytoplasm, cytoskeleton, Membrane, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, Mitochondrion, Mitochondrion outer membrane

Uniprot	Q00005
Database Links	HGNC:9305 OMIM:604325 KEGG:hsa:5521 STRING:9606.ENSP00000336591 UniGene:Hs.627618
Function	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity).
Pathway	Hippo signaling pathway PI3K-Akt signaling pathway AMPK signaling Sphingolipid signaling pathway
Protein Families	Phosphatase 2A regulatory subunit B family
Tissue Specificity	Brain.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558672	CSB-PA168178	100ul	$297		Add to Cart

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