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Home / Antibodies

PPP2CA Antibody

SKU : BHA10559063

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA574686
Alternative Names	PR52A; PR55A; B55A; B55ALPHA;
Categories	Primary Antibodies
Clonality	polyclonal
Description	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Yu, X.X. et al. (2001) Mol. Biol. Cell 12, 185-199. Tolstykh, T. et al. (2000) EMBO J. 19, 5682-5691. Janssens, V. and Goris, J. (2001) Biochem. J. 353, 417-439.
Host	Rabbit
Immunogen	Peptide Corresponding to the amino terminal sequence derived from Human PP2A-alpha.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Yu, X.X. et al. (2001) Mol. Biol. Cell 12, 185-199. Tolstykh, T. et al. (2000) EMBO J. 19, 5682-5691. Janssens, V. and Goris, J. (2001) Biochem. J. 353, 417-439.
Species	Homo Sapiens (Human)
Specificity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Subcellular Location	Cytoplasm, Nucleus, Chromosome, centromere, Cytoplasm, cytoskeleton, spindle pole

Uniprot	P67775
Database Links	HGNC:9299 OMIM:176915 KEGG:hsa:5515 STRING:9606.ENSP00000418447 UniGene:Hs.105818
Function	PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
Pathway	Hippo signaling pathway PI3K-Akt signaling pathway TGF-beta signaling pathway Autophagy AMPK signaling
Protein Families	PPP phosphatase family, PP-1 subfamily

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559063	CSB-PA574686	100ul	$297		Add to Cart

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