Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.Hagerty L, et al. (2007) J Biol Chem. 2007; 282(7):4884-93Seok YM, et al. (2008) J Pharmacol Exp Ther. Niiro N et al. (2003) Biochem J. 2003 ;369(Pt 1):117-28
Host
Rabbit
Immunogen
Peptide sequence around aa.36~40 (R-V-T-V-K) derived from Human CPI17a.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Hagerty L, et al. (2007) J Biol Chem. 2007; 282(7):4884-93 Seok YM, et al. (2008) J Pharmacol Exp Ther. Niiro N et al. (2003) Biochem J. 2003 ;369(Pt 1):117-28
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of total CPI17a protein.
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Pathway
Vascular smooth muscle contraction
Protein Families
PP1 inhibitor family
Tissue Specificity
Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.