Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.Saleh A. Bakheet, Toxicol. Sci., Feb 2007; 95: 436 - 442. Michael Hagmann, Nucleic Acids Res., Feb 1995; 23: 4978 - 4985. C.Peter Verrijzer, Nucleic Acids Res., Dec 1992; 20: 6369 - 6375. V¨¦ronique Goffin, Nucleic Acids Res., Aug 2005; 33: 4285 - 4310.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human OCT2 antibody.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.
Saleh A. Bakheet, Toxicol. Sci., Feb 2007; 95: 436 - 442. Michael Hagmann, Nucleic Acids Res., Feb 1995; 23: 4978 - 4985. C.Peter Verrijzer, Nucleic Acids Res., Dec 1992; 20: 6369 - 6375. V¨¦ronique Goffin, Nucleic Acids Res., Aug 2005; 33: 4285 - 4310.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total OCT2 protein.
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.
Protein Families
POU transcription factor family, Class-2 subfamily
Tissue Specificity
Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.