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Home / Antibodies

POU2F1 Antibody

SKU : BHA10559087

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA184871
Alternative Names	1-Oct; OTF1; oct-1B
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. Prefontaine G.G., Walther R., Giffin W. J. Biol. Chem. 274:26713-26719(1999) Mahajan S.S., Wilson A.C. Mol. Cell. Biol. 20:919-928(2000)
Host	Rabbit
Immunogen	Peptide sequence around aa.270~274(T-P-K-R-I) derived from Human Oct-1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. Prefontaine G.G., Walther R., Giffin W. J. Biol. Chem. 274:26713-26719(1999) Mahajan S.S., Wilson A.C. Mol. Cell. Biol. 20:919-928(2000)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Oct-1 protein.
Subcellular Location	Nucleus

Uniprot	P14859
Database Links	HGNC:9212 OMIM:164175 KEGG:hsa:5451 STRING:9606.ENSP00000356840 UniGene:Hs.283402
Function	Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
Protein Families	POU transcription factor family, Class-2 subfamily
Tissue Specificity	Ubiquitous. Isoform 2 is lymphocyte-specific.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:1000
IF	1:100-1:200

Tested Application

ELISA,WB,IF;WB:1:500-1:1000,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559087	CSB-PA184871	100ul	$297		Add to Cart

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